✔✔👀👀Senior Scientist, Mass Spectrometry @Merck & Co., Inc✔✔👀👀
Job Description
The Bioanalytical LC-MS Lab within the Pharmacokinetics (PK), Pharmacodynamics and Drug Metabolism (PPDM) organization at our South San Francisco location is seeking an exceptional LC-MS Bioanalyst to contribute to the understanding of the PK properties of novel therapeutic drug candidates across modalities (small molecule, peptide, large molecule)
Through close collaboration with a cross-functional team of talented scientists, the responsibilities of the position include:
Independently design, plan and implement LC-MS based assays to quantify and characterize therapeutic proteins, peptides, and small molecules of interest in pre-clinical studies within tight timelines.
This comprises of the following:
Developing robust sample preparation methods ranging from affinity purification preparation method to protein precipitation / SPE clean-up method using automation solutions such as Bravo assay Map, KingFisher, and Hamilton liquid handlers.
Optimizing LC-MS conditions on a variety of triple-quad instruments for quantitation and high-resolution instruments for biotransformation and metID.
Effectively analyzing and interpreting results through a range of software including Skyline, Analyst, PepFinder, MassLynx, Genedata Expressionist, Phoenix, and Watson.
Delivering high quality quantitative or qualitative data to project teams for PK and PK / PD analysis
Effectively documenting, tracking, and communicating scientific findings and recommendations within cross-functional teams.
Representing and leading discovery cross-functional teams
Contributing to establishing and maintaining bioanalytical lab operations
Required experience/skills:
Strong hands-on experience with different chromatographic separation and mass spectrometry methodologies for quantitative and qualitative analysis of therapeutic proteins, biomarkers, or small molecules.
Experience with proteomics, biochemistry methods, and analysis of post-translational modifications of large therapeutic proteins is a plus.
Ability to work efficiently and multitask in a fast-paced environment is a must.
Excellent verbal and written communication skills.
Successful candidate provides first-authored, internal and external reports and presentations on technical and scientific findings.
Fosters team-based approach to research. Committed to working synergistically and harmoniously with others.
While the work environment is non-GLP (Discovery stage) basic knowledge of regulated bioanalysis is a plus
Experience in working with outside providers / CROs is a plus
Automation and programming skills also a plus.
Basic Qualifications
Doctorate degree by March 2021 OR
Master’s degree & 4 years of scientific experience OR
Bachelor’s degree & 6-7 years of scientific experience
Preferred Qualifications
PhD in analytical chemistry, analytical chemistry or related field
MS in analytical chemistry, analytical chemistry or related field
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada, and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit, and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
INVENT.
IMPACT.
INSPIRE.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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Employee Status:
Regular
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